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Hotkeys and Startup Programs

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I ran CCleaner today. I saw HOTKEYS and was not sure what they are, do I delete them? Also Under TOOLS, Startup, all these programs that load at startup, are they necessary. If I delete them, what will that do? There are some programs loading that I am sure I don't need at startup, but will the program be unaffected? Will the programs load again at startup at some other point in time?

 

I am very cautious running anything that DELETES. When I run my spyware programs, anything it finds I save to a quarantine file, in case I find out later that I need some file.

 

Thanks!!

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