[Defraggler and windows 10 Defrag tool show very different defragmentation]

Thanks for your responses. Most of my fragmented files are large and over 64mb, so that is why windows does not see them as fragmented.

Some of these drives are 6-8tb and only have 5% space left. Some files are 2-10gb movie files. Would you recommend choosing the "move large files to end of drive" option?

 

8 hours ago, Andavari said:

In my opinion when using 3rd party defrag tools on the system disk where Windows is installed it's better to just have them defrag only the fragmented files, i.e.; via the file list like what Defraggler and umpteen others have and then let Windows itself deal with optimization. If you do things that way your defrag's will be done surprisingly fast, you won't have to disable the built in optimization, and the built in optimization won't have to undo a ton of stuff 3rd party defrag tools do differently.

Are you referring to doing the quick defrag instead of the full defrag?

 

[Defraggler and windows 10 Defrag tool show very different defragmentation]

For some reason on some of my drives defraggler shows 20%, 35%,50% fragmentation but windows built in tool shows 0% fragmentation for them. Is this normal that the two are so different? 

[How does ccleaner mark a startup item as disabled and do they become enabled once uninstalling ccleaner?]

I only ask because I just ran the program "autoruns" and it was picking up all my disabled startup items as enabled. Is this because ccleaner itself keeps disabling the items at every startup manually and there is not some global startup disablement location that ccleaner and autoruns both have access to see?