OK, if I understand correctly your suggestion, this is a trick to create an exclude entry in INI file that I can manually modify later. However I am very prudent unless you are REALLY sure it works. In fact, if Defraggler has problem to "see" or "access" the file to exclude it by GUI, I wonder if it will be able to recognize it and really exclude it if I insert it in INI file. If it does not work, I will be no more able to access my laptop, forever. No way to recover a damaged PGP protected HD.
I would prefer if a future version of Defraggler would support PGP encrypted disks. I would feel more comfortable.