Old thread but I just set up Defraggler Portable and spent time trying to set up the .ini file options to no purpose. It would be efficasciou if it were noted in the help that those who want Boot Time Defrag should use the installer version.
The other thing I noticed was that a "Quick Defrag" would probably run for 6 hours if I let it. I'd hate to see how long the slow defrag would take.
Anyway, I did get the Boot Time Defrag of C:. It only took a few seconds since I have the page file configured so that it cannot be fragmented. I was just curious.