I have the same issue
Windows XP SP3
Speccy ver. 1.08.218
I'm using Avast! antivirus
CCleaner and Defraggler run fine without any problem.
Speccy worked fine just before I ran CCleaner. I figured Ccleaner had probably deleted something usesful to speccy in the registry, so I uninstalled and re-installed Speccy. That didn't fix anything.
Edit :
Everything runs fine again after a reboot