First off: the New Defraggler runs great but with one problem. Let me say that I like the new interface and the quickness of the product. The problem is in the boot time defragmantation process. I have been using Piriform products for a while now (actual time unknown.) At this point I have CCleaner, Defraggler, and Speccy installed. All have done a wonderful job but I know that bootime defrag can be a tricky endeavor.
Here is how things went: I completed a defrag and then set up for a boot time defrag. It asked me if I wanted to restart so I said yes. The computer promply shutdown and restarted. It started to defrag and then stopped giving the error that a hive in the registry could not be loaded. It then reset and restarted. No damage to the system.
The other day, I did a sfc/scannow with no problems found. I keep the registry clean.
Asus M4A77D MB
2.2 Ghz Athlon 64x2
2G ram
WD 500G sata2 HD
Asus EN9500GT/DI/1GD2/V2 graphics card
Windows Vista Sp2 all updates
Internet Explorer 9beta