I use defraggler for a long time, and i like it so much.
but i obsreved that it dowsn't defrag the system files, 'cause theyre in use, so it can't be modified.
so my suggestion is: Make a defraggler bootable cd. just like the GParted Live (but gparted os not a defragmentig tool).
so, if you could run Defraggler from a CD, you could defrag all the system files.
it will be very useful.
thank you