After using 3.01 and rebooting this is what I get for index.dat. Cookies and Low\History.IE5 looks normal. But TIF\Content.IE5 at 1,015,808 doesn't seem right. I thought a "clean" index.dat defaults to about 32KB.
Directory of D:\Profiles\IEData\Cookies
11/29/2010 08:42 PM 32,768 index.dat
1 File(s) 32,768 bytes
Directory of D:\Profiles\IEData\History\History.IE5
11/29/2010 08:42 PM 65,536 index.dat
1 File(s) 65,536 bytes
Directory of D:\Profiles\IEData\History\History.IE5\MSHist012010112920101130
11/29/2010 08:42 PM 32,768 index.dat
1 File(s) 32,768 bytes
Directory of D:\Profiles\IEData\History\Low\History.IE5
11/26/2010 09:49 PM 16,384 index.dat
1 File(s) 16,384 bytes
Directory of D:\Profiles\IEData\IECompatCache
11/27/2010 06:02 PM 360,448 index.dat
1 File(s) 360,448 bytes
Directory of D:\Profiles\IEData\Temporary Internet Files\Content.IE5
11/29/2010 08:42 PM 1,015,808 index.dat
1 File(s) 1,015,808 bytes