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Its best to use one anti virus , as others have mentioned here ,two or more resident AV may conflict with each other.
I use Avast! 4 Home version and its been great for me. I turned on the automatic Updates. And they have lots of easy to replace Skins to suit your taste.
I feel very confident in avast AV protection and they have quick answering support on questions I asked them.. Also recommend the avast Forum ..
My former AV was Norton version 2005 internet security and it was using too much of my computer resources , so I removed it couple of months ago.
I have 2 PC's one windows 98 SE with avast AV and the other XP Sp2 that came with McAfee, but I will also place avast on the XP computer ibefore year end.