I understand and that is what I currently do,
I pull the hard drive from the infected system, put it in a USB external enclosure and fire it up.
Then I go under each user account (with XP) and delete the temporary files and IE temporary files.
This speeds virus and malware scanning tremendously!
My question was, How do I tell CCleaner that I want it to clean drive X: instead of my C:?
I'm not asking it to clean malware or virus, just clean the junk off so the scanners run faster. (all of those temp files slow down scanning!)