Hi, I came to the forum because I had pretty much the same problem so I hope someone can help out. Running on vista business 64, registery cleaner lists a bunch of "ActiveX/COM Issues" that mainly have to do with winamp which I recently uninstalled. Also some obsolete software keys. They basically keep showing up after fixing them. I'm running CCleaner as administrator. I thought perhaps I need to disable windows defender, but I'm not sure how to do that. Is there is a better program for cleaning up windows vista 64?