A little update on my ThreatFire experience . . .
For several months I've been using Threatfire 4.1 with absolutely no problems or conflicts whatsoever. However, just yesterday, I realized there was a newer version (4.5), so I decided to upgrade. Nothing else on my system had changed, but it immediately started flagging all sorts of things (false positives) that the earlier version hadn't. The bottom line is that it quickly became a real pain in the neck and I ended up uninstalling it and re-installing 4.1.
Of course, all of this could be totally unique to my computer, but in that I just recently posted some positive comments about this app, I thought I should share these latest developments.